硕士生导师

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张全

发布日期:2024-11-03 浏览量:

一、基本信息

张全,男,四川资中人,博士、副教授、硕士生导师,学院药学技能实验教学中心主任,学院药物研究所副所长。本科毕业于成都中医药大学中药学专业,2012年和2015年分别于四川大学华西beat365正版唯一官网获得药剂学硕士、博士学位。2021年入选第十三批四川省学术与技术带头人后备人选。中国医药教育协会中医药慢病防治工程委员会常务委员、中国中医药信息学会中医临床药学分会理事、四川省医学会药物及器械临床评价与研究专业委员会委员、四川省分析测试学会色谱专业委员会委员;研究方向为微粒靶向递药系统及其应用、成药性优化研究。主持了国家自然科学基金等纵向课题8项,横向研究课题11项;以第一作者或通讯作者发表SCI论文20余篇;申请发明专利10余项,授权专利5项;参编教材2部;招收培养硕士生14名。

二、主持科学研究项目

1.国家自然科学基金项目,81603045,成纤维细胞激活蛋白响应的肿瘤及肿瘤微环境双靶向给药系统的研究,2017/01-2019/12,17万,结题。

2.四川省自然科学基金项目,2023NSFSC1683,程序性释放STING激动剂和PDGFR拮抗剂的肿瘤靶向递药体系构建及其用于实体瘤免疫治疗的研究,2023/01-2024/12,10万,在研。

3.Natura Biotechnologies Pte Ltd(新加坡)横向合作项目,BRECARE的安全性及药效学评价,2024/05-2027/05,35万,在研。

三、主要讲授课程

1. 硕士研究生:学研究实验技术与技能

2. 本科生课程:药学综合性与设计性实验,无机化学实验,工业药剂学

四、主要代表性成果

代表性论文

1) Caifeng Deng†,Quan Zhang†, Mengdi Jia, Jin Zhao, Xun Sun,TaoGong*, Zhirong Zhang. Tumors and their microenvironment dual-targeting chemotherapy with local immune adjuvant therapy for effective antitumor immunity against breastcancer.Advanced Science, 2019, 6:1801868.IF = 15.804.

2) Caifeng Deng,Quan Zhang, Penghui He, Bin Zhou, Ke He, Xun Sun, Guanghua Lei*, Tao Gong*, Zhirong Zhang. Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis. Nature Communications, 2021, 12:2174.IF = 14.919.高被引论文

3) Jiamin Mao, Xiaoyuan Liu, Lie Zhang, Yu Chen, Shiyu Zhou, Yujiao Liu, Jing Ye, Xiaohong Xu, Quang Zhang*. Self-nanoemulsifying Drug Delivery System of Morin: A New Approach for Combating Acute Alcohol Intoxication. Internation Journal of Nanomedicine. 2024, 19:10569-10588.IF = 6.6.

4) Jianxia Dong, Shu Wang, Jiamin Mao*, Zhidan Wang, Shiying Zhao, Qiao Ren, Jialing Kang, Jing Ye, Xiaohong Xu, Yujin Zhu,Quan Zhang*. Preparation of dihydromyricetin-loaded self-emulsifying drug delivery system and its anti-alcoholism effect. Pharmaceutics, 2023, 15:2296.IF = 5.4.

5) Shian Lai†,Quan Zhang†, Lin Jin*. Natural and man-made cyclic peptide-based antibiotics. Antibiotics-Basel, 2023, 12:42.IF = 4.8.

6) Qiao Ren, Shiying Zhao, Yujin Zhu, Jiamin Mao, Xiaoyuan Liu, Jing Ye,Quan Zhang*, Xiaohong Xu. Supramolecular aggregates of myricetin improve its bioavailability and its role in counteracting alcoholism. Journal of Drug Delivery Science and Technology, 2022, 74:103515.IF = 5.062.

7) Jing Ye†, Sha Bao†, Shiying Zhao, Yujing Zhu, Qiao Ren, Rui Li, Xiaohong Xu,Quan Zhang*. Self-assembled micelles improve the oral bioavailability of dihydromyricetin and anti-acute alcoholism activity. AAPS PharmSciTech, 2021, 22:111.IF = 4.026.

8) Caifeing Deng†, Xiaohong Xu, DrunpTashi,Yongmei Wu,Bingyin Su,Quan Zhang†*. Co-administration of biocompatible self-assembled polylactic acid- hyaluronic acid block copolymer nanoparticles with tumor-penetrating peptide-iRGD for metastatic breast cancer therapy. Journal of Materials Chemistry B, 2018, 6:3163- 3180.IF = 4.543.

9) Caifeng Deng,Quan Zhang*,YaoFu, Xun Sun,TaoGong*, Zhirong Zhang. Coadministration of oligomeric hyaluronic acid-modified liposomes with tumor- penetrating peptide-iRGD enhances the antitumor efficacy of doxorubicin against melanoma. ACS Applied Materials & Interfaces, 2017, 9:1280-1292.IF = 8.097.

10) Quan Zhang†, Xuanmiao Zhang†, Tijia Chen, Xinyi Wang, Yao Fu, Yun Jin*, Xun Sun, Tao Gong*, Zhirong Zhang. A safe and efficient hepatocyte-selective carrier system based on myristoylated preS1/21-47 domain of hepatitis B virus. Nanoscale, 2015, 7: 9298-9310.IF = 7.760.

授权专利

1) 张全;邓彩凤; 许小红;叶静;陈煜;一种多酚类物质的超分子纳米胶体及其制备方法,2023-9-6,中国,ZL202311142606.4.

2) 张全;邓彩凤; 许小红;毛家敏;刘小媛;叶静;桑色素的新用途、及其自乳化给药系统和制备方法,2023-6-21,中国,ZL202310739668.7.

3) 张全;许小红;朱昱锦;鲍莎;叶静;一种具有抗肿瘤作用的药物组合物,2020-1-20,中国,ZL202010066532.0.

4) 张全;许小红;朱昱锦;鲍莎;叶静;一种糖脂类抗原注射液及其制备方法,2020-1-20,中国,ZL202010066576.3.

5) 张全;许小红;叶静;鲍莎;朱昱锦;一种2,4-二硝基苯酚脂肪乳及其制备方法和用途,2019-7-30,中国,ZL201910697033.9.

教材及论著

1) 药学基础实验教程,杨红、汪维鹏主编,人民卫生出版社,2022.12,副主编

2) 生物药剂学与药物动力学,鲁卫东、张景勍主编,科学出版社,2017.01,编委

五、联系方式

E-mail:zhangquancdmc@126.com;276456512@qq.com

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