一、基本信息
吴敏,教授,医学博士,生物医学工程博士后,硕士生导师,第4批、第5批四川省中医药管理局学术和技术带头人后备人选,第12批四川省卫生计生委学术技术带头人及后备人选,四川省食品药品审查评价及安全监测中心药品注册检查员(2011-2022年)。主要从事纳米医药研究。近年主持6项科研项目,其中厅局级项目3项,四川省医学会项目1项,校级项目1项,临床科学研究基金项目1项。作为一作和通讯作者共发表科研论文22篇,其中中文核心与科技核心共计12篇,SCI共10篇。获授权专利3项。荣获全国优秀药学硕士教学案例3项;荣获四川省2021年教学成果奖二等奖1项,第一届全国药学专业学位研究生教育教学成果二等奖1项,学院教学成果校级二等奖1项。
二、主持科学研究项目
1. 对中药复方水煎自沉淀的二次开发——共沉淀法构建泡腾纳米粒(2021-MS200),四川省中医药管理局,2021.05.15-2023.05.15,主持,3万元
2. EVO/BER@LB-MSNs的构建及其抗肿瘤作用研究(17ZA0110),四川省教育厅重点项目,2017-2019,主持,2万元
3.旋覆花属植物挥发油中倍半萜类肿瘤多药耐药逆转剂及对MDR细胞膜通透性研究(13ZA0209),四川省教育厅重点项目,2013-2015,主持,2.6万元
三、主持教学研究项目
1. 2023年全国药学专业学位“精品案例课堂”建设项目:“多烯磷脂酰胆碱微胞注射剂补充申请案例”。
2. 2021-2023年四川省省级教改课题:“药学硕士“多情景-多维度”案例教学实施研究”(JG2021-1204)。
3.2021年第三批四川省高等学校省级课程思政示范项目课程《药物新剂型与制剂新技术(全案例课程)》(SZ2022031)。
四、主要讲授课程
1. 硕士研究生:药物新剂型与制剂新技术
2. 本科生课程:药剂学
五、主要代表性成果
[1] Tianyu Chen, Hui Chen, Yichun Jiang, Qi Yan, Shuling Zheng, Min Wu. Co-Delivery of 5-Fluorouracil and Paclitaxel in Mitochondria-Targeted KLA-Modified Liposomes to Improve Triple-Negative Breast Cancer Treatment. Pharmaceuticals, 2022, 15, 881.
[2] Huanli Yin, Qi Yan, Yuan Liu, Lan Yang, Yang Liu, Yujie Luo, Tianyu Chen, Ningxi Li, Min Wu. Co-encapsulation of paclitaxel and 5-fluorouracil in folic acid-modified, lipid-encapsulated hollow mesoporous silica nanoparticles for synergistic breast cancer treatment [J]. RSC Adv., 2022, 12, 32534-32551.
[3] Tianyu Chen, Yichun Jiang, Changmao Wang, Zhengxue Cai, Hui Chen, Junliang Zhu, Pinrun Tao, Min Wu*. The pH-triggered drug release and simultaneous carrier decomposition of effervescent SiO2-drug-Na2CO3 composite nanoparticles: to improve the antitumor activity of hydrophobic drugs[J]. RSC Advances, 2021, 11(10): 5335-5347.
[4] Ningxi Li, Yan Chen, Huimin Sun, Tingwenli Huang, Tianyu Chen, Yichun Jiang, Qian Yang, Xianyan Yan, Min Wu. Decreasing acute toxicity and suppressing colorectal carcinoma using Sorafenib-loaded nanoparticles[J]. Pharmaceutical Development and Technology, 2020, 25(5): 556-565.
[5] Yi Feng, Huanli Yin, Xue Zhao, Min Wu. LC-MS/MS Determination of Evodiamine in Plasma and Its Pharmacokinetics in Rats after Administration in the Form of Solid Lipid Nanoparticles[J]. Current Pharmaceutical Analysis, 2020, 16, 231-237.
[6] Tianyu Chen, Tianqiang Wu, Ningxi Li, Yichun Jiang, Huanli Yin, Min Wu. Simulation-based comparison of Biopharmaceutics Classification System and drug structure[J]. Pharmazie, 2020, 75: 124-130.
[7] Yi Feng, Ning-xi Li, Huan-li Yin, Tian-yu Chen, Qian Yang, Min Wu. Thermo- and pH-responsive, Lipid-coated, Mesoporous Silica Nanoparticle-based Dual Drug Delivery System to Improve the Antitumor Effect of Hydrophobic Drugs[J]. Molecular Pharmaceutics, 2019, 16(1): 422-436.
[8] Huan-li Yin, Lang-tao Wang, Min Wu, Yuan Liu, Ning-xi Li, Tian-yu Chen. Cyanidin-3-O-glucoside chloride acts synergistically with luteolin to inhibit the growth of colon and breast carcinoma cells [J]. Pharmazie, 2019, 74(1): 54-61.
[9] Min Wu, Tingting Li, Lilan Chen, Sugang Peng, Wei Liao, Ruolan Bai, Xue Zhao,Hong Yang, Chunhui Wu, Hongjuan Zeng, Yiyao Liu*.Essential oils from Inula japonica and Angelicae dahuricae enhance sensitivity of MCF-7/ADR breast cancer cells to doxorubicin via multiple mechanisms. Journal of Ethnopharmacology, 180: 18-27, 2016.
[10] Min Wu, Lin Sun, Ziyan Yuan Pessetto, Zhihe Zang, Xingliang Xie, Ling Zhong, Qing Su, Wang Zan, Xiurong Gao, Yan Zhao, Yiyi Sun*. Casitas B-Lineage Lymphoma RING Domain Inhibitors Protect Mice against High-Fat Diet-Induced Obesity and Insulin Resistance. PLoS ONE, 10(8): e0135916. doi:10.1371/journal.2015.
六、联系方式
E-mail:496600716@qq.com